![]() For instance, gene expression values are ranked to identify the top-most list of expressed genes, based on an arbitrary expression threshold, or a set of gene expression experiments are clustered, each cluster defining a potentially large gene list. ![]() Especially in more mature fields, like gene expression microarrays, the statistical models used for gene scoring are well established. For instance, a frequently applied method is to score genes by their differential expression between two biological states (such as healthy vs. Gene lists are typically defined using statistical methods appropriate to the experimental design. ![]() High-throughput genomic experiments often lead to the identification of large gene lists. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Andrew Emili acknowledges funding from the Ontario Research Fund and the Heart and Stroke Foundation of Canada. Bader acknowledges funding from the US National Institutes of Health (NIH) via National Human Genome Research Institute (NHGRI) grant P41 P41HG04118, the Canada Foundation for Innovation and Ontario Research Fund (ORF) and Genome Canada via the Ontario Genomics Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Gary D. ![]() Received: FebruAccepted: OctoPublished: November 15, 2010Ĭopyright: © 2010 Merico et al. PLoS ONE 5(11):Įditor: Timothy Ravasi, King Abdullah University of Science and Technology, Saudi Arabia Citation: Merico D, Isserlin R, Stueker O, Emili A, Bader GD (2010) Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |